Bub3 è un gene codificato dal simbolo BUB3. È noto anche come Mitotic checkpoint protein BUB3. Bub3 ha una massa di 37.16kDa e una lunghezza di amminoacidi di 328.
Offriamo 10 anticorpi contro Bub3, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Sommario di Entrez
This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Somiglianze di sequenza
Belongs to the WD repeat BUB3 family.
Modifica post-translazionale
Poly-ADP-ribosylated by PARP1.
Posizione cellulare
Nucleus. Chromosome > Centromere > Kinetochore.
Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition.
