BTF è un gene codificato dal simbolo BCLAF1. Altri nomi includono: Bcl-2-associated transcription factor 1; BCLAF1 and THRAP3 family member 1; BCLAF1; KIAA0164. BTF ha una massa di 106.12kDa e una lunghezza di amminoacidi di 920.
Offriamo 7 anticorpi contro BTF, allevati nel Coniglio, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
Sommario di Entrez
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Ubiquitous.
Somiglianze di sequenza
Belongs to the BCLAF1/THRAP3 family.
Modifica post-translazionale
Citrullinated by PADI4.
Posizione cellulare
Cytoplasm. Nucleus. Nucleus speckle. Nucleus > Nucleoplasm.
