BMP7 è un gene codificato dal simbolo BMP7. Altri nomi includono: Bone morphogenetic protein 7; BMP-7; Osteogenic protein 1; OP-1; OP1. BMP7 ha una massa di 49.31kDa e una lunghezza di amminoacidi di 431.
Offriamo 11 anticorpi contro BMP7, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo, Ratto, Maiale, Pollo e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Promotes brown adipocyte differentiation by P38 MAPK pathway-mediated activation of target genes, including members of the SOX family of transcription factors (PubMed:27923061).
Sommario di Entrez
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients.
Specificità del tessuto
Expressed in the kidney and bladder. Lower levels seen in the brain.
Somiglianze di sequenza
Belongs to the TGF-beta family.
Modifica post-translazionale
Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms.
Posizione cellulare
Secreted.
