Bik è un gene codificato dal simbolo BIK. Altri nomi includono: Bcl-2-interacting killer; Apoptosis inducer NBK; BIP1; BP4; NBK. Bik ha una massa di 18.02kDa e una lunghezza di amminoacidi di 160.
Offriamo 9 anticorpi contro Bik, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoting activity. Does not interact with BAX.
Sommario di Entrez
The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins.
Modifica post-translazionale
Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism.
Posizione cellulare
Endomembrane system. Mitochondrion membrane.
Around the nuclear envelope, and in cytoplasmic membranes.
