Bcl2L2 è un gene codificato dal simbolo BCL2L2. Altri nomi includono: Bcl-2-like protein 2; Bcl2-L-2; Apoptosis regulator Bcl-W; BCLW; KIAA0271. Bcl2L2 ha una massa di 20.75kDa e una lunghezza di amminoacidi di 193.
Offriamo 10 anticorpi contro Bcl2L2, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Sommario di Entrez
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene.
Specificità del tessuto
Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.
Somiglianze di sequenza
Belongs to the Bcl-2 family.
Posizione cellulare
Mitochondrion membrane.
Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.
