BACH1.3 è un gene codificato dal simbolo BACH1. Altri nomi includono: Transcription regulator protein BACH1; BTB and CNC homolog 1; HA2303; BACH1. BACH1.3 ha una massa di 81.96kDa e una lunghezza di amminoacidi di 736.
Offriamo 10 anticorpi contro BACH1.3, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498).
Sommario di Entrez
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene.
Somiglianze di sequenza
Belongs to the bZIP family. CNC subfamily.
Modifica post-translazionale
Ubiquitinated by the SCF(FBXL17) complex, leading to its degradation by the proteasome.
Posizione cellulare
Nucleus.
