Aquaporin 5 è un gene codificato dal simbolo AQP5. Altri nomi includono: Aquaporin-5; AQP-5; AQP5. Aquaporin 5 ha una massa di 28.29kDa, una lunghezza di amminoacidi di 265, ed è implicato in Keratoderma, palmoplantar, Bothnian type.
Offriamo 10 anticorpi contro Aquaporin 5, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo, Ratto, Bovino e Pecora.
Informazioni su geni e proteine
Riepilogo UniProt
Forms a water-specific channel (PubMed:8621489, PubMed:18768791). Plays an important role in fluid secretion in salivary glands (By similarity). Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723). Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity).
Sommario di Entrez
Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.
Specificità del tessuto
Detected in skin eccrine sweat glands, at the apical cell membrane and at intercellular canaliculi (at protein level).
Coinvolgimento nella malattia
Keratoderma, palmoplantar, Bothnian type: A dermatological disorder characterized by diffuse non-epidermolytic hyperkeratosis of the skin of palms and soles. PPKB is frequently complicated by fungal infections.
Somiglianze di sequenza
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Posizione cellulare
Apical cell membrane. Cell membrane. Cytoplasmic vesicle membrane.
Hypotonicity increases location at the cell membrane. Phosphorylation decreases location at the cell membrane.
