APLP1 è un gene codificato dal simbolo APLP1. Altri nomi includono: Amyloid-like protein 1; APLP. APLP1 ha una massa di 72.18kDa e una lunghezza di amminoacidi di 650.
Offriamo 6 anticorpi contro APLP1, allevati nel Coniglio, che sono adatti per WB, IHC e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
Sommario di Entrez
This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.
Specificità del tessuto
Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).
Somiglianze di sequenza
Belongs to the APP family.
Modifica post-translazionale
Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3 (By similarity).
Posizione cellulare
Cell membrane.
