Apg12 è un gene codificato dal simbolo ATG12. Altri nomi includono: Ubiquitin-like protein ATG12; Autophagy-related protein 12-like; ATG12L. Apg12 ha una massa di 15.11kDa e una lunghezza di amminoacidi di 140.
Offriamo 11 anticorpi contro Apg12, allevati nel Coniglio e Capra, che sono adatti per WB, IHC e ICC/IF con campioni derivati da Umano, Topo, Ratto, Scimmia e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes.
Sommario di Entrez
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998
Specificità del tessuto
Ubiquitous.
Somiglianze di sequenza
Belongs to the ATG12 family.
Modifica post-translazionale
Acetylated by EP300.
Posizione cellulare
Cytoplasm. Preautophagosomal structure membrane.
TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
