ANKRD1 è un gene codificato dal simbolo ANKRD1. Altri nomi includono: Ankyrin repeat domain-containing protein 1; Cardiac ankyrin repeat protein; Cytokine-inducible gene C-193 protein; Cytokine-inducible nuclear protein; C193; CARP; HA1A2. ANKRD1 ha una massa di 36.25kDa, una lunghezza di amminoacidi di 319, ed è implicato in Total anomalous pulmonary venous return.
Offriamo 8 anticorpi contro ANKRD1, allevati nel Coniglio, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells.
Sommario di Entrez
The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.
Specificità del tessuto
Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells.
Coinvolgimento nella malattia
Total anomalous pulmonary venous return: Rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births.
Posizione cellulare
Nucleus.
