Angiopoietin 2 è un gene codificato dal simbolo ANGPT2. Altri nomi includono: Angiopoietin-2; ANG-2; ANGPT2. Angiopoietin 2 ha una massa di 56.92kDa e una lunghezza di amminoacidi di 496.
Offriamo 6 anticorpi contro Angiopoietin 2, allevati nel Coniglio, che sono adatti per WB e IHC con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Sommario di Entrez
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
Posizione cellulare
Secreted.
