AMHR2 è un gene codificato dal simbolo AMHR2. Altri nomi includono: Anti-Muellerian hormone type-2 receptor; Anti-Muellerian hormone type II receptor; AMH type II receptor; MIS type II receptor; MISRII; AMHR; MISR2. AMHR2 ha una massa di 62.75kDa, una lunghezza di amminoacidi di 573, ed è implicato in Persistent Muellerian duct syndrome 2.
Offriamo 11 anticorpi contro AMHR2, allevati nel Coniglio, Capra e Human, che sono adatti per WB, IHC, ELISA e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Sommario di Entrez
This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified.
Coinvolgimento nella malattia
Persistent Muellerian duct syndrome 2: A form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Posizione cellulare
Membrane.
