alpha 2 Macroglobulin è un gene codificato dal simbolo A2M. Altri nomi includono: Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; A2M; CPAMD5. alpha 2 Macroglobulin ha una massa di 163.29kDa e una lunghezza di amminoacidi di 1474.
Offriamo 36 anticorpi contro alpha 2 Macroglobulin, allevati nel Coniglio, Topo, Capra, Ratto e Sheep, che sono adatti per WB, IHC, ELISA, ICC/IF e RIA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Sommario di Entrez
The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
Specificità del tessuto
Secreted in plasma.
Somiglianze di sequenza
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
Posizione cellulare
Secreted.
