alpha 1 Fetoprotein è un gene codificato dal simbolo AFP. Altri nomi includono: Alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin; AFP; HPAFP. alpha 1 Fetoprotein ha una massa di 68.68kDa, una lunghezza di amminoacidi di 609, ed è implicato nella malattia: Alpha-fetoprotein deficiency; Alpha-fetoprotein, hereditary persistence.
Offriamo 52 anticorpi contro alpha 1 Fetoprotein, allevati nel Coniglio, Topo, Capra e Sheep, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso, IP, Dot, ChIP e RIA con campioni derivati da Umano, Topo, Ratto, Maiale, Scimmia e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties.
Sommario di Entrez
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
Specificità del tessuto
Plasma. Synthesized by the fetal liver and yolk sac.
Coinvolgimento nella malattia
Alpha-fetoprotein deficiency: A benign condition characterized by undetectable AFP levels in the amniotic fluid. Affected individuals are asymptomatic and present normal development.
Alpha-fetoprotein, hereditary persistence: A benign autosomal dominant condition characterized by continued expression of alpha-fetoprotein in adult life.
Somiglianze di sequenza
Belongs to the ALB/AFP/VDB family.
Modifica post-translazionale
Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence.
Posizione cellulare
Secreted.
