alpha 1 Antichymotrypsin è un gene codificato dal simbolo SERPINA3. Altri nomi includono: Alpha-1-antichymotrypsin; ACT; Cell growth-inhibiting gene 24/25 protein; Serpin A3; SERPINA3; AACT. alpha 1 Antichymotrypsin ha una massa di 47.65kDa e una lunghezza di amminoacidi di 423.
Offriamo 32 anticorpi contro alpha 1 Antichymotrypsin, allevati nel Coniglio e Topo, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Sommario di Entrez
The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.
Specificità del tessuto
Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
Somiglianze di sequenza
Belongs to the serpin family.
Modifica post-translazionale
N- and O-glycosylated.
Posizione cellulare
Secreted.
