AIM2 è un gene codificato dal simbolo AIM2. È noto anche come Interferon-inducible protein Absent in melanoma 2. AIM2 ha una massa di 38.95kDa e una lunghezza di amminoacidi di 343.
Offriamo 14 anticorpi contro AIM2, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Sommario di Entrez
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
Specificità del tessuto
Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.
Somiglianze di sequenza
Belongs to the HIN-200 family.
Posizione cellulare
Nucleus. Cytoplasm.
Activated inflammasomes can aggregate in the cytosol as speck-like particles.
