ADK è un gene codificato dal simbolo ADK. Altri nomi includono: Adenosine kinase; AK; Adenosine 5'-phosphotransferase. ADK ha una massa di 40.55kDa, una lunghezza di amminoacidi di 362, ed è implicato in Hypermethioninemia due to adenosine kinase deficiency.
Offriamo 7 anticorpi contro ADK, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Sommario di Entrez
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Widely expressed. Highest level in placenta, liver, muscle and kidney.
Coinvolgimento nella malattia
Hypermethioninemia due to adenosine kinase deficiency: A metabolic disorder characterized by global developmental delay, early-onset seizures, mild dysmorphic features, and characteristic biochemical anomalies, including persistent hypermethioninemia with increased levels of S-adenosylmethionine and S-adenosylhomocysteine. Homocysteine levels are typically normal.
Somiglianze di sequenza
Belongs to the carbohydrate kinase PfkB family.
Posizione cellulare
Nucleus.
