ADCY3 è un gene codificato dal simbolo ADCY3. Altri nomi includono: Adenylate cyclase type 3; ATP pyrophosphate-lyase 3; Adenylate cyclase type III; AC-III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3; AC3; KIAA0511. ADCY3 ha una massa di 128.96kDa, una lunghezza di amminoacidi di 1144, ed è implicato in Obesity.
Offriamo 7 anticorpi contro ADCY3, allevati nel Coniglio e Pollo, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo, Ratto e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
Sommario di Entrez
This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle (PubMed:9920776). Detected in testis (PubMed:15705663).
Coinvolgimento nella malattia
Obesity: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Somiglianze di sequenza
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Modifica post-translazionale
Sumoylated. Sumoylation is required for targeting ot olfactory cilia.
Posizione cellulare
Cell membrane. Cytoplasm. Cell projection > Cilium. Golgi apparatus.
Also detected in the cytoplasm, close to lipid droplets.
