ADAMTS1 è un gene codificato dal simbolo ADAMTS1. Altri nomi includono: A disintegrin and metalloproteinase with thrombospondin motifs 1; ADAM-TS 1; METH-1; KIAA1346; METH1. ADAMTS1 ha una massa di 105.36kDa e una lunghezza di amminoacidi di 967.
Offriamo 6 anticorpi contro ADAMTS1, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
Sommario di Entrez
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.
Modifica post-translazionale
The precursor is cleaved by a furin endopeptidase.
Posizione cellulare
Secreted > Extracellular space > Extracellular matrix.
