Tissue Factor è un gene codificato dal simbolo F3. È noto anche come: TF; Coagulation factor III; Thromboplastin; F3. Tissue Factor ha una massa di 33.07kDa e una lunghezza di amminoacidi di 295.
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Informazioni su geni e proteine
Riepilogo UniProt
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Sommario di Entrez
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.
Specificità del tessuto
Lung, placenta and pancreas.
Somiglianze di sequenza
Belongs to the tissue factor family.
Posizione cellulare
Membrane.
