TGF alpha è un gene codificato dal simbolo TGFA. È noto anche come: Protransforming growth factor alpha; TGFA. TGF alpha ha una massa di 17.01kDa e una lunghezza di amminoacidi di 160.
Offriamo 15 TGF alpha ELISA kit per il rilevamento qualitativo o quantitativo di TGF alpha da campioni di Umano, Topo, Ratto, Maiale, Coniglio e Scimmia.
Informazioni su geni e proteine
Riepilogo UniProt
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
Sommario di Entrez
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines.
Posizione cellulare
Secreted > Extracellular space.
