IL15 è un gene codificato dal simbolo IL15. Comunemente indicato anche come: Interleukin-15; IL-15. IL15 ha una massa di 18.09kDa e una lunghezza di amminoacidi di 162.
Offriamo 26 IL15 ELISA kit per il rilevamento qualitativo o quantitativo di IL15 da campioni di Umano, Topo, Ratto, Bovino, Maiale, Coniglio, Pollo, Cane e Porcellino d'India.
Informazioni su geni e proteine
Riepilogo UniProt
Cytokine that stimulates the proliferation of T-lymphocytes (PubMed:8178155). Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (PubMed:8178155). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (PubMed:15123770).
Sommario di Entrez
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported.
Specificità del tessuto
Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.
Somiglianze di sequenza
Belongs to the IL-15/IL-21 family.
Posizione cellulare
Secreted.
