IGFBP3 è un gene codificato dal simbolo IGFBP3. Comunemente indicato anche come: Insulin-like growth factor-binding protein 3; IBP-3; IBP3. IGFBP3 ha una massa di 31.67kDa e una lunghezza di amminoacidi di 291.
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Informazioni su geni e proteine
Riepilogo UniProt
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Sommario di Entrez
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Specificità del tessuto
Expressed by most tissues. Present in plasma.
Modifica post-translazionale
Phosphorylated by FAM20C in the extracellular medium.
Posizione cellulare
Secreted.
