Pepsinogen II è un gene codificato dal simbolo PGC. Comunemente indicato anche come: Gastricsin; Pepsinogen C; PGC. Pepsinogen II ha una massa di 42.43kDa e una lunghezza di amminoacidi di 388.
Offriamo 1 Pepsinogen II ELISA kit per il rilevamento qualitativo o quantitativo di Pepsinogen II da campioni di Umano.
Informazioni su geni e proteine
Riepilogo UniProt
Hydrolyzes a variety of proteins.
Sommario di Entrez
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
Somiglianze di sequenza
Belongs to the peptidase A1 family.
Posizione cellulare
Secreted.
