Osteoprotegerin è un gene codificato dal simbolo TNFRSF11B. Comunemente indicato anche come: Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; TNFRSF11B; OCIF; OPG. Osteoprotegerin ha una massa di 46.03kDa, una lunghezza di amminoacidi di 401, ed è implicato in Paget disease of bone 5, juvenile-onset.
Offriamo 17 Osteoprotegerin ELISA kit per il rilevamento qualitativo o quantitativo di Osteoprotegerin da campioni di Umano, Topo, Ratto, Maiale, Coniglio, Scimmia e Pollo.
Informazioni su geni e proteine
Riepilogo UniProt
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
Sommario di Entrez
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
Specificità del tessuto
Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
Coinvolgimento nella malattia
Paget disease of bone 5, juvenile-onset: An autosomal recessive, juvenile-onset form of Paget disease, a disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. PDB5 clinical manifestations include short stature, progressive long bone deformities, fractures, vertebral collapse, skull enlargement, and hyperostosis with progressive deafness.
Modifica post-translazionale
N-glycosylated. Contains sialic acid residues.
Posizione cellulare
Secreted.
