IP10 è un gene codificato dal simbolo CXCL10. Comunemente indicato anche come: C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein; Gamma-Small-inducible cytokine B10; CXCL10; INP10; SCYB10. IP10 ha una massa di 10.88kDa e una lunghezza di amminoacidi di 98.
Offriamo 10 IP10 ELISA kit per il rilevamento qualitativo o quantitativo di IP10 da campioni di Umano, Topo, Ratto, Bovino, Maiale e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:7540647, PubMed:11157474, PubMed:22652417). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12750173, PubMed:12663757). Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).
Sommario di Entrez
This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression.
Specificità del tessuto
Mainly secreted by monocytes, endothelial cells as well as fibroblasts. Expressed by epithelial cells in thymus (PubMed:11157474). Microglial cells produce CXCL10 in response to viral stimulation (PubMed:12663757).
Somiglianze di sequenza
Belongs to the intercrine alpha (chemokine CxC) family.
Modifica post-translazionale
Several proteases can mediate post-secretion cleavages. DPP4 cleaves CXCL10 on its N-terminal 2 amino acids leading to an antagonist form of CXCL10. This dominant negative form is capable of binding CXCR3 but does not induce signaling. MMP9 cleaves 9 amino acids instead.
Posizione cellulare
Secreted.
