IL17F è un gene codificato dal simbolo IL17F. Comunemente indicato anche come: Interleukin-17F; IL-17F; Cytokine ML-1. IL17F ha una massa di 18.05kDa, una lunghezza di amminoacidi di 163, ed è implicato in Candidiasis, familial, 6.
Offriamo 15 IL17F ELISA kit per il rilevamento qualitativo o quantitativo di IL17F da campioni di Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity).
Sommario di Entrez
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.
Specificità del tessuto
Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.
Coinvolgimento nella malattia
Candidiasis, familial, 6: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.
Somiglianze di sequenza
Belongs to the IL-17 family.
Posizione cellulare
Secreted.
