IL11 è un gene codificato dal simbolo IL11. Comunemente indicato anche come: Interleukin-11; IL-11; Adipogenesis inhibitory factor; AGIF. IL11 ha una massa di 21.43kDa e una lunghezza di amminoacidi di 199.
Offriamo 13 IL11 ELISA kit per il rilevamento qualitativo o quantitativo di IL11 da campioni di Umano, Topo, Ratto e Maiale.
Informazioni su geni e proteine
Riepilogo UniProt
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.
Sommario di Entrez
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Somiglianze di sequenza
Belongs to the IL-6 superfamily.
Posizione cellulare
Secreted.
