IL1 alpha è un gene codificato dal simbolo IL1A. Comunemente indicato anche come: Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1; IL1A; IL1F1. IL1 alpha ha una massa di 30.61kDa e una lunghezza di amminoacidi di 271.
Offriamo 37 IL1 alpha ELISA kit per il rilevamento qualitativo o quantitativo di IL1 alpha da campioni di Umano, Topo, Ratto, Bovino, Maiale, Coniglio, Scimmia, Cane, Goat, Porcellino d'India e Cavallo.
Informazioni su geni e proteine
Riepilogo UniProt
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Sommario di Entrez
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
Somiglianze di sequenza
Belongs to the IL-1 family.
Posizione cellulare
Secreted.
The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.
