FLAP è un gene codificato dal simbolo ALOX5AP. Altri nomi includono: Arachidonate 5-lipoxygenase-activating protein; MK-886-binding protein; ALOX5AP. FLAP ha una massa di 18.16kDa, una lunghezza di amminoacidi di 161, ed è implicato in Ischemic stroke.
Offriamo 2 FLAP ELISA kit per il rilevamento qualitativo o quantitativo di FLAP da campioni di Umano e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Sommario di Entrez
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Coinvolgimento nella malattia
Ischemic stroke: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Somiglianze di sequenza
Belongs to the MAPEG family.
Posizione cellulare
Nucleus membrane. Endoplasmic reticulum membrane.
