ETS1 è un gene codificato dal simbolo ETS1. Altri nomi includono: Protein C-ets-1; p54; EWSR2. ETS1 ha una massa di 50.41kDa e una lunghezza di amminoacidi di 441.
Offriamo 7 ETS1 ELISA kit per il rilevamento qualitativo o quantitativo di ETS1 da campioni di Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
Sommario di Entrez
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Specificità del tessuto
Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.
Somiglianze di sequenza
Belongs to the ETS family.
Modifica post-translazionale
Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity.
Posizione cellulare
Cytoplasm. Nucleus.
Delocalizes from nucleus to cytoplasm when coexpressed with isoform Ets-1 p27.
