DUSP1 è un gene codificato dal simbolo DUSP1. Altri nomi includono: Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; Protein-tyrosine phosphatase CL100; CL100; MKP1; PTPN10; VH1. DUSP1 ha una massa di 39.3kDa e una lunghezza di amminoacidi di 367.
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Informazioni su geni e proteine
Riepilogo UniProt
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
Sommario di Entrez
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy.
Specificità del tessuto
Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.
Somiglianze di sequenza
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Modifica post-translazionale
Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation.
Posizione cellulare
Nucleus.
