CCR1 è un gene codificato dal simbolo CCR1. Altri nomi includono: C-C chemokine receptor type 1; C-C CKR-1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CMKBR1; CMKR1; SCYAR1. CCR1 ha una massa di 41.17kDa e una lunghezza di amminoacidi di 355.
Offriamo 3 CCR1 ELISA kit per il rilevamento qualitativo o quantitativo di CCR1 da campioni di Umano, Topo e Bovino.
Informazioni su geni e proteine
Riepilogo UniProt
Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.
Sommario di Entrez
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.
Specificità del tessuto
Widely expressed in different hematopoietic cells.
Somiglianze di sequenza
Belongs to the G-protein coupled receptor 1 family.
Posizione cellulare
Cell membrane.
