BNIP3 è un gene codificato dal simbolo BNIP3. Altri nomi includono: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; NIP3. BNIP3 ha una massa di 27.83kDa e una lunghezza di amminoacidi di 259.
Offriamo 3 BNIP3 ELISA kit per il rilevamento qualitativo o quantitativo di BNIP3 da campioni di Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
Sommario di Entrez
This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation.
Somiglianze di sequenza
Belongs to the NIP3 family.
Posizione cellulare
Mitochondrion. Mitochondrion outer membrane.
Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.
