beta Defensin 1 è un gene codificato dal simbolo DEFB1. Altri nomi includono: Beta-defensin 1; BD-1; Defensin, beta 1; DEFB1; BD1; HBD1. beta Defensin 1 ha una massa di 7.42kDa e una lunghezza di amminoacidi di 68.
Offriamo 16 beta Defensin 1 ELISA kit per il rilevamento qualitativo o quantitativo di beta Defensin 1 da campioni di Umano, Topo, Ratto, Bovino, Maiale e Goat.
Informazioni su geni e proteine
Riepilogo UniProt
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636).
Sommario di Entrez
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis.
Specificità del tessuto
Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).
Somiglianze di sequenza
Belongs to the beta-defensin family.
Posizione cellulare
Secreted. Membrane.
Associates with tumor cell membrane-derived microvesicles (PubMed:23938203).
