Amphiregulin è un gene codificato dal simbolo AREG. Altri nomi includono: AR; Colorectum cell-derived growth factor; CRDGF; AREG; AREGB; SDGF. Amphiregulin ha una massa di 27.9kDa e una lunghezza di amminoacidi di 252.
Offriamo 10 Amphiregulin ELISA kit per il rilevamento qualitativo o quantitativo di Amphiregulin da campioni di Umano, Topo, Ratto, Bovino e Maiale.
Informazioni su geni e proteine
Riepilogo UniProt
Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Sommario di Entrez
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions.
Somiglianze di sequenza
Belongs to the amphiregulin family.
Posizione cellulare
Membrane.
