alpha Defensin 1 è un gene codificato dal simbolo DEFA1. Altri nomi includono: Neutrophil defensin 1; Defensin, alpha 1; HNP-1; HP-1; DEFA1; DEF1; DEFA2; MRS. alpha Defensin 1 ha una massa di 10.2kDa e una lunghezza di amminoacidi di 94.
Offriamo 4 alpha Defensin 1 ELISA kit per il rilevamento qualitativo o quantitativo di alpha Defensin 1 da campioni di Umano e Topo.
Informazioni su geni e proteine
Riepilogo UniProt
Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.
Sommario di Entrez
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
Somiglianze di sequenza
Belongs to the alpha-defensin family.
Modifica post-translazionale
ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production.
Posizione cellulare
Secreted.
