Anti-PPAR delta Anticorpo [PCRP-PPARD-4C2] (A315528)

Anti-PPAR delta Antibody [PCRP-PPARD-4C2]

Mouse monoclonal [PCRP-PPARD-4C2] antibody to PPAR delta.

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that can be activated by a variety of compounds including fibratus, thiazolidinediones, prostaglandins and fatty acids. Three PPAR subtypes, designated PPARa, PPARb (also designated PPAR) and PPARg, have been described. PPARs promote transcription by forming heterodimers with members of the retinoid X receptor (RXR) family of steroid receptors and binding to specific DNA motifs termed PPAR-response elements (PPREs). PPARa is abundant in primary hepatocytes, where it regulates the expression of proteins involved in fatty acid metabolism. PPARb is the most widely distributed subtype and is often expressed at high levels. PPARg is predominantly seen in adipose tissue, where it plays a critical role in regulating adipocyte differentiation. Interestingly, both the orphan nuclear hormone receptor LXRa and thyroid receptor (TR) have been shown to act as antagonists of PPARa/ RXRa binding to PPREs.

Flow Cytometry

HeLa or MCF-7 cells.

Flow Cytometry: 1-2 µg/million cells

Human

This antibody is predicted to cross react with Chicken.

Recombinant fragment (around Amino Acids 72-146) of human PPARD protein.

Mouse

Monoclonal

PCRP-PPARD-4C2

Unconjugated

Protein A/G chromatography.

200 µg/ml

49.9 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

FAAR, MGC3931, NR1C2, NUC1, NUCI, NUCII, Nuclear hormone receptor 1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferative activated receptor delta, Peroxisome proliferator-activated receptor beta, Peroxisome proliferator-activated receptor beta (PPAR-beta), Peroxisome proliferator-activated receptor delta, PPAR beta, PPAR-beta, PPAR-delta, PPAR-ß, PPARB, ppard, PPARD_HUMAN