Anti-PPAR delta Anticorpo (A283082)

Anti-PPAR delta Antibody

Rabbit polyclonal antibody to PPAR delta.

This antibody recognises peroxisome proliferator-activated receptor, delta (PPARD), a member of the nuclear hormone receptor subfamily. Upon activation, PPARD forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. PPARD controls genes involved in lipid metabolism, and enhances fatty acid catabolism and energy uncoupling in adipose tissue and skeletal muscle.PPARD has also been implicated in the proliferation and differentiation of preadipocytes, enterocytes, keratinocytes and the placenta.PPARD agonists could be used therapeutically to target multiple components of the metabolic syndrome, including insulin resistance, hyperglycemia, dyslipidemia, and atherosclerosis.

WB, ELISA

ELISA: 1:30,000 - 1:70,000, WB: 1:500 - 1:2,000

Mouse, Rabbit, Chimpanzee, Rat, Human

Synthetic peptide corresponding to amino acids 1-14 of mouse PPAR delta.

MEQPQEETPEAREE

Rabbit

Polyclonal

IgG

Unconjugated

Approximately 55 kDa in heart whole cell lysates.

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti PPRAD antibody detects peroxisome proliferator-activated receptor, delta (PPARD), a member of the nuclear hormone receptor subfamily. Upon activation, PPARD forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. PPARD controls genes involved in lipid metabolism, and enhances fatty acid catabolism and energy uncoupling in adipose tissue and skeletal muscle. PPARD has also been implicated in the proliferation and differentiation of preadipocytes, enterocytes, keratinocytes and the placenta. PPARD agonists could be used therapeutically to target multiple components of the metabolic syndrome, including insulin resistance, hyperglycemia, dyslipidemia, and atherosclerosis.

FAAR, MGC3931, NR1C2, NUC1, NUCI, NUCII, Nuclear hormone receptor 1, Nuclear receptor subfamily 1 group C member 2, Peroxisome proliferative activated receptor delta, Peroxisome proliferator-activated receptor beta, Peroxisome proliferator-activated receptor beta (PPAR-beta), Peroxisome proliferator-activated receptor delta, PPAR beta, PPAR-beta, PPAR-delta, PPAR-ß, PPARB, ppard, PPARD_HUMAN