Anti-PLK1 Anticorpo [PLK1/7122] (A315519)

Anti-PLK1 Antibody [PLK1/7122]

Mouse monoclonal [PLK1/7122] antibody to PLK1.

Plk (for polo-like kinase) encodes a serine/threonine kinase that is closely related to polo and CDC5, genes that are required for passage through mitosis in Drosophila and Saccharomyces, respectively. Polo and CDC5 both code for proteins that are involved in regulating the function of the mitotic spindle. Plk protein accumulates in the cell during the S and G2 phases of the cell cycle; Plk protein content and catalytic activity peak at the onset of mitosis, followed by a rapid reduction after mitosis. Plk expression is detectable in mitotically active tissues such as colon and placenta, as well as in tumors of various origins. It has also been suggested that Plk may serve as a marker of cell proliferation.

ELISA, IHC-P

Human tonsil, spleen or thymus.

IHC: 1-2 µg/ml

Human

Recombinant fragment of human PLK1 protein (around Amino Acids 1-200). The exact sequence is proprietary.

Mouse

Monoclonal

PLK1/7122

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

66 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Cell cycle regulated protein kinase, PLK, PLK 1, PLK-1, PLK1_HUMAN, Polo like kinase 1, Polo-like kinase 1, Serine/threonine protein kinase 13, Serine/threonine protein kinase PLK1, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase PLK1, STPK 13, STPK13