Anti-Plakophilin 1 Anticorpo [10B2] (A249637)

Anti-Plakophilin 1 Antibody [10B2]

Mouse monoclonal [10B2] antibody to Plakophilin 1.

This antibody recognizes a protein of 75kDa, identified as Plakophilin-1. Its epitope maps between aa 1-27 human Plakophilin-1. Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart.

Flow Cytometry, IF, WB

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml

Human, Mouse

N terminal fragment of human Plakophilin-1 protein.

Mouse

Monoclonal

10B2

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

75 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Plakophilin 1 Antibody [10B2] - BSA and Azide free (A252817).

B6P, Band 6 protein, PKP1, Plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)