Anti-PI 3 Kinase p85 beta Anticorpo [PIK3R2/292] (A277748)

Anti-PI 3 Kinase p85 beta Antibody [PIK3R2/292]

Mouse monoclonal [PIK3R2/292] antibody to PI 3 Kinase p85 beta.

Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. p110 L expression is restricted to white blood cells. It has been shown to bind p85α and p85β, but it apparently does not phosphorylate these subunits. p110 L seems to have the capacity to autophosphorylate. p110γ does not interact with the p85 subunits. It has been shown to be activated by α and βγ heterotrimeric G proteins.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 520-720, of human PIK3R2 protein. The exact sequence is proprietary.

Mouse

Monoclonal

PIK3R2/292

IgG2b

kappa

Unconjugated

200 µg/ml

85 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-PI 3 Kinase p85 beta Antibody [PIK3R2/292] - BSA and Azide free (A278336).

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