Anti-PDGF BB Anticorpo [AB06-1E10] (A279623)

Anti-PDGF BB Antibody [AB06-1E10]

Mouse monoclonal [AB06-1E10] antibody to PDGF BB.

This antibody recognises the homodimer of platelet-derived growth factor subunit B (PDGF-B) also known as PDGF-2, PDGF beta chain and PDGF beta polypeptide. PDGF-BB is a member of the PDGF growth factor family which is made up of 4 isoforms (A, B, C and D). PDGF-BB is a homodimer of the B isoform which is able to bind all three of the PDGF receptors to trigger various signaling pathways including Ras-MAPK, PI3K, PLC?, and JAK. Activation of these pathways lead to transcription of PDGF target genes playing roles in embryogenesis, and in adults under physiological conditions, roles in tissue repair, wound healing and maturation of blood vessels and white adipocytes. The purified Mouse anti Human PDGF-BB antibody, clone AB06-1E10 (MCA6264GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human PDGF-BB antibody, clone AB13-3G6 (MCA6265B) as the detection antibody.

ELISA

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length PDGF-BB (Ser82-Thr190).

Mouse

Monoclonal

AB06-1E10

IgG1

Unconjugated

Protein G affinity chromatography of tissue culture supernatant.

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human PDGF-BB antibody, clone AB06-1E10, recognizes the homodimer of platelet-derived growth factor subunit B (PDGF-B) also known as PDGF-2, PDGF beta chain and PDGF beta polypeptide. PDGF-BB is a member of the PDGF growth factor family which is made up of 4 isoforms (A, B, C and D). PDGF-BB is a homodimer of the B isoform which is able to bind all three of the PDGF receptors to trigger various signaling pathways including Ras-MAPK, PI3K, PLC?, and JAK (Evrova & Buschmann 2017). Activation of these pathways lead to transcription of PDGF target genes playing roles in embryogenesis, and in adults under physiological conditions, roles in tissue repair, wound healing and maturation of blood vessels and white adipocytes (Saplacan et al. 2017).The purified Mouse anti Human PDGF-BB antibody, clone AB06-1E10 (MCA6264GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human PDGF-BB antibody, clone AB13-3G6 (MCA6265B) as the detection antibody.

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