Anti-PD-L1 Anticorpo [29E.2A3] (APC) (A279152)

$635

Anticorpo monoclonale [29E.2A3] di topo contro PD-L1 (APC) per Flow Cytometry.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-PD-L1 Antibody [29E.2A3] (APC)
Descrizione
Mouse monoclonal [29E.2A3] antibody to PD-L1 (APC).
Specificità
This antibody recognises human CD274, also known as B7-H1 and PD-1L, a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T cells, B cells, endothelial cells and epithelial cells in response to interferons alpha, beta and gamma.CD274 is reported to possess dual functions; inhibition of activated effector T cells and co-stimulation of naïve T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to co-stimulate early T cell priming and differentiation.Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection, as well as in many autoimmune diseases and cancers.
Applicazioni
Flow Cytometry
Diluizioni consigliate
Flow Cytometry: Neat, Use 10µl of the suggested working dilution to label 1x106 cells in 100µl
Reattività
Human, Primate
Immunogeno
Full length human CD274.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
29E.2A3
Isotipo
IgG2b
Coniugare

APC

Excitation: 645nm, Emission: 660nm

Purificazione
Protein A affinity chromatography of tissue culture supernatant.
Concentrazione
Lot Specific
Purezza
>95% (by SDS-PAGE).
Forma del prodotto
Liquid
Formulazione
Supplied in Phosphate Buffered Saline with 0.2% BSA and <0.1% Sodium Azide.
Conservazione
Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light.
Note generali
Mouse anti Human CD274 antibody, clone 29E.2A3 detects human CD274, also known as B7-H1 and PD-1L, a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules. CD274 is expressed constitutively on macrophages and dendritic cells, and is induced on activated T cells, B cells, endothelial cells and epithelial cells in response to interferons alpha, beta and gamma.CD274 is reported to possess dual functions; inhibition of activated effector T cells and co-stimulation of naïve T cells. CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1; PD-1) leading to the secretion of the regulatory cytokine interleukin-10. CD274 has also been shown to co-stimulate early T cell priming and differentiation.Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection, as well as in many autoimmune diseases and cancers.
Sinonimi
B7 H, B7 H1, B7 homolog 1, B7-H1, B7H, B7H1, CD 274, CD274, CD274 antigen, CD274 molecule, MGC142294, MGC142296, OTTHUMP00000021029, PD L1, PD1L1_HUMAN, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL 1, PDL1, Programmed cell death 1 ligand 1, Programmed death ligand 1, RGD1566211
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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