Anti-PCGF3 Anticorpo [PCRP-PCGF3-1D5] (A315481)

Anti-PCGF3 Antibody [PCRP-PCGF3-1D5]

Mouse monoclonal [PCRP-PCGF3-1D5] antibody to PCGF3.

Polycomb group (PcG) proteins form multiprotein complexes that regulate expression patterns of developmental and cell proliferation genes. Several members of the PcG contain ring finger domains and are identified as a subclass of RING finger proteins. The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteinerich domain that is able to bind two zinc atoms. Proteins that contain the RING-type zinc finger conserved domain are generally involved in the ubiquitination pathway of protein degradation. PCGF3 (polycomb group ring finger 3), also known as RNF3, DONG1 or RNF3A, is a 242 amino acid transcriptional regulator that is encoded by a gene located on human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. PCGF3 exists as two isoforms produced by alternative splicing events.

Flow Cytometry, IF, IHC-P

HeLa or MCF-7 cells. Human brain, testis or smooth muscle.

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC: 1-2 µg/ml

Human

Recombinant full-length human PCGF3 protein.

Mouse

Monoclonal

IgG2b

Unconjugated

Protein A/G chromatography.

200 µg/ml

28.12Da

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

DONG1, PCGF3_HUMAN, Polycomb group ring finger 3, Polycomb group RING finger protein 3, Ring finger protein 3, RING finger protein 3A, RNF3A