Anti-PAX6 Anticorpo [PAX6/7708] (A316861)

Anti-PAX6 Antibody [PAX6/7708] - BSA and Azide free

Mouse monoclonal [PAX6/7708] antibody to PAX6.

Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.

IHC-P

Human pancreas or cerebellum.

IHC: 1-2 µg/ml

Human

Recombinant fragment (N-terminus; aa 1-300) of human PAX6 protein.

Mouse

Monoclonal

PAX6/7708

Unconjugated

Protein A/G chromatography.

1 mg/ml

47 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

AN, AN 2, AN2, Aniridia type II protein, D11S812E, FVH1, KIAA0552, Leucine zipper putative tumor suppressor 3, LZTS3, MGC17209, MGDA, Oculorhombin, Paired box 6, Paired Box Gene 6, Paired box gene 6 (aniridia keratitis), Paired box homeotic gene 6, Paired box protein Pax-6, Paired box protein Pax6, PAX 6, PAX6_HUMAN, ProSAP-interacting protein 1, PROSAPIP1, Sey, WAGR