Anti-pan Cytokeratin Anticorpo [KRTL/1077 + KRTH/1076] (A250839)

Anti-pan Cytokeratin Antibody [KRTL/1077 + KRTH/1076]

Mouse monoclonal [KRTL/1077 + KRTH/1076] antibody to pan Cytokeratin.

Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which include CK1, CK3, CK4, CK5, CK6, CK8, CK10, CK14, CK15, CK16, and CK19. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. KRTL/KRTH is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.

IHC-P

IHC-P: 1-2 µg/ml

Human, Rat

Recombinant human KRT77 and KRT76 protein.

Mouse

Oligoclonal

KRTL/1077 + KRTH/1076

Unconjugated

Protein A/G chromatography.

200 µg/ml

67 kDa (CK1) / 64 kDa (CK3) / 59 kDa (CK4) / 58 kDa (CK5) / 56 kDa (CK6) / 52 kDa (CK8) / 56.5 kDa (CK10) / 50 kDa (CK14) / 50 kDa (CK15) / 48 kDa (CK16) / 40 kDa (CK19)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.