Ricombinante Anti-p57 Kip2 Anticorpo [rKIP2/7238] (A315443)

$765

Anticorpo monoclonale [rKIP2/7238] di topo contro p57 Kip2 per IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-p57 Kip2 Antibody [rKIP2/7238]
Descrizione
Recombinant mouse monoclonal [rKIP2/7238] antibody to p57 Kip2.
Specificità
Recognizes a protein of 57kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.
Applicazioni
IHC-P
Controllo positivo
Human colon or prostate carcinomas.
Diluizioni consigliate
IHC: 0.25-0.5 µg/ml
Reattività
Human
Immunogeno
Recombinant full-length human p57Kip2 protein.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
rKIP2/7238
Isotipo
IgG
Catene leggere
kappa
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
200 µg/ml
Peso molecolare
57 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sinonimi
Beckwith Wiedemann syndrome, BWCR, BWS, CDKI, CDKN 1C, CDKN1C, CDN1C_HUMAN, Cyclin dependent kinase inhibitor 1C, Cyclin dependent kinase inhibitor p57, Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, KIP 2, KIP2, p57, p57 Kip 2, p57KIP2, WBS
Controlli isotipo
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

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