Ricombinante Anti-p21 Anticorpo [CIP1/4377R] (A248091)

Name: Anti-p21 Antibody [CIP1/4377R]
Brand: Antibodies.com
SKU: A248091
Price: 525.0 USD
Availability: InStock

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$525

Anticorpo monoclonale [CIP1/4377R] di coniglio contro p21 per IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Consegna

Spese di spedizione

$40

Tempi di consegna

4-6 Giorni lavorativi

Contattaci

Telefono

+1 (314) 370-6046

E-mail

orders@antibodies.com

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Anticorpo Ricombinante

Descrizione Prodotto

Nome

Anti-p21 Antibody [CIP1/4377R]

Descrizione

Recombinant rabbit monoclonal [CIP1/4377R] antibody to p21.

Specificità

This antibody recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This antibody is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).

Applicazioni

IHC-P

Diluizioni consigliate

IHC-P: 1-2 µg/ml

Reattività

Human

Immunogeno

Synthetic peptide corresponding to amino acids 1-100 of p21 protein.

Specie ospite

Rabbit

Clonalità

Monoclonal

Clona ID

CIP1/4377R

Isotipo

IgG

Coniugare

Unconjugated

Purificazione

Protein A/G chromatography.

Concentrazione

200 µg/ml

Peso molecolare

21 kDa

Forma del prodotto

Liquid

Formulazione

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Conservazione

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Note generali

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-p21 Antibody [CIP1/4377R] - BSA and Azide free (A251274).

Sinonimi

CAP20, CDK-interacting protein 1, CDKI, CDKN1, Cdkn1a, CDN1A_HUMAN, CIP1, Cyclin Dependent Kinase Inhibitor 1A, Cyclin-dependent kinase inhibitor 1, Cyclin-dependent kinase inhibitor 1A (P21), Cyclin-dependent kinase inhibitor 1A (p21, Cip1), DNA Synthesis Inhibitor, MDA-6, MDA6, Melanoma differentiation-associated protein, Melanoma differentiation-associated protein 6, P21 protein, p21CIP1, p21Cip1/Waf1, p21WAF, PIC1, SDI1, SLC12A9, WAF1, Wild type p53 activated fragment 1, Wild type p53 activated fragment 1 (WAF1), Wildtype p53-activated fragment 1

Controlli isotipo

Secondari adatti

Dichiarazione di non responsabilità

Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.

Immagini (3)

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Figure 1: Immunohistochemistry - Anti-p21 Antibody [CIP1/4377R] (A248091)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon carcinoma using Anti-p21 Antibody [CIP1/4377R].

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Figure 2: Immunohistochemistry - Anti-p21 Antibody [CIP1/4377R] (A248091)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human lungcarcinoma using Anti-p21 Antibody [CIP1/4377R].

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Figure 3: Anti-p21 Antibody [CIP1/4377R] (A248091)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-p21 Antibody [CIP1/4377R]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.