Ricombinante Anti-p16INK4a Anticorpo [rCDKN2A/4845] (A278466)

Anticorpo monoclonale [rCDKN2A/4845] di topo contro p16INK4a per WB e IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Spese di spedizione
Tempi di consegna
4-6 Giorni lavorativi
Telefono
+1 (314) 370-6046
Lun - Ven, 8:00 - 16:00 AST
E-mail
orders@antibodies.com
Nome
Anti-p16INK4a Antibody [rCDKN2A/4845] - BSA and Azide free
Descrizione
Recombinant mouse monoclonal [rCDKN2A/4845] antibody to p16INK4a.
Specificità
p16INK4a is a tumor suppressor protein. It is a specific inhibitor of cdk4/cdk6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia. Expression of p16INK4a (p16 positive) is highly correlated with human papilloma virus (HPV) infection in head and neck squamous cell carcinomas (HNSCC). p16 status is an important prognostic indicator in HNSCC and the p16 positive/HPV16 negative group is likely a distinct subgroup lacking any HPV genotype.
Applicazioni
WB, IHC-P
Diluizioni consigliate
WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml
Reattività
Human
Immunogeno
Recombinant full-length human p16INK4a protein, expressed in and purified from E. coli.
Specie ospite
Mouse
Clonalità
Monoclonal
Clona ID
rCDKN2A/4845
Isotipo
IgG2a
Catene leggere
kappa
Coniugare

Unconjugated

Purificazione
Protein A/G chromatography.
Concentrazione
1 mg/ml
Peso molecolare
14 kDa
Forma del prodotto
Liquid
Formulazione
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Conservazione
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Note generali
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-p16INK4a Antibody [rCDKN2A/4845] (A277878).
Dichiarazione di non responsabilità
Questo prodotto è solo per uso di ricerca. Non è inteso per uso diagnostico o terapeutico.
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